Influence of tramadol on functional recovery of acute spinal cord injury in rats

Abstract Purpose: To evaluate the influence tramadol on functional recovery of acute spinal cord injury in rats. Methods: Ten rats were divided into two groups (n = 5). All animals were submitted by a laminectomy and spinal cord injury at eighth thoracic vertebra. In control group, the rats didn't receive any analgesic. In tramadol group, the rats received tramadol 4mg/Kg at 12/12h until 5 days by subcutaneous. Animals were following by fourteen days. Was evaluated the Basso, Beattie, Bresnahan scale (locomotor evaluation) and Rat Grimace Scale (pain evaluation) at four periods. Results: There no difference between the groups in locomotor evaluation in all periods evaluated (p>0.05) and in both groups there was a partial recover of function. The tramadol group show a lower pain levels at the first, third and seventh postoperatively days when comparing to the control group. Conclusion: The tramadol as an analgesic agent don't influence on functional recovery of acute spinal cord injury in rats

Influence of tramadol on functional recovery of acute spinal cord injury in rats.

PURPOSE: To evaluate the influence tramadol on functional recovery of acute spinal cord injury in rats. METHODS: Ten rats were divided into two groups (n = 5). All animals were submitted by a laminectomy and spinal cord injury at eighth thoracic vertebra. In control group, the rats didn't receive any analgesic. In tramadol group, the rats received tramadol 4mg/Kg at 12/12h until 5 days by subcutaneous. Animals were following by fourteen days. Was evaluated the Basso, Beattie, Bresnahan scale (locomotor evaluation) and Rat Grimace Scale (pain evaluation) at four periods. RESULTS: There no difference between the groups in locomotor evaluation in all periods evaluated (p>0.05) and in both groups there was a partial recover of function. The tramadol group show a lower pain levels at the first, third and seventh postoperatively days when comparing to the control group. CONCLUSION: The tramadol as an analgesic agent don't influence on functional recovery of acute spinal cord injury in rats.

Perfil do marcador bioquímico de lesão miocárdica creatinoquinase-MB (CK-MB) em pacientes portadores do vírus HIV/AIDS / Profile of biochemical marker of myocardial injury creatine kinase-MB (CK-MB) in patients with HIV/AIDS

Objetivo: analisar o perfil da creatinoquinase-MB (CK-MB) em pacientes com diagnósticosorológico positivo de HIV/AIDS, caracterizando os achados clínicos e o perfil do referidomarcador bioquímico de lesão miocárdica. Método: estudo transversal relacionando os perfisséricos de creatinoquinase-MB, creatinoquinase total, potássio, aspartato aminotransferase ealanina aminotransferase com os achados de comprometimento cardíaco de quarenta e cincopacientes, sendo 13 do sexo masculino e 32 do sexo feminino. Resultados: os resultadosdemonstraram que, apesar da maioria dos pacientes serem sintomáticos, nenhum pacienteapresentou elevação da creatinoquinase-MB. Portanto, o referido marcador bioquímico nãopode ser utilizado com indicador de lesão miocárdica na síndrome da imunodeficiênciaadquirida

Objective: examine the behaviour of enzyme creatine kinase-MB in patients with HIV/AIDSmet at the Municipal Laboratory "Epaminondas Wendler," in the city of Cascavel, duringNovember-December of 2010 in the State of Paraná. Through a study on which werecharacterized the symptoms clinics and profile from the marked biochemical of myocardialinjury. Methods: It was determined serious profiles of creatine kinase-MB, creatinine kinase,urea, creatinina, potassium, aspartataminetransferase and alanineaminetranferase relationed withthe symptoms clinics of the cardiac muscles inflammable process. Results: The results showthat in spite of the great part of the patient be symptomatic, just 12,76% show elevation serumfrom creatine kinase-MB. However, the referred marked biochemical can?t be utilized asindicated of injury cardiac in syndrome da imunodeficiência/AIDS

Terapia nutricional enteral em crianças com câncer: uma revisão de literatura / Enteral nutritional therapy in children with cancer: a review

Objetivo: Realizou-se uma revisão bibliográfica sobre a terapia nutricional enteral em pacientes pediátricos com câncer. Método: revisão narrativa com busca sistemática de dados nas bases PUBMED, MEDLINE, CAPES e SCIELO. Resultados: foram utilizados 26 artigos científicos diretamente relacionados ao assunto, 4 de referências relacionadas e 2 capítulos de livros. Considerações finais: durante anos a nutrição parenteral foi a terapia nutricional mais utilizada em casos de crianças com câncer. No entanto, tal conduta está sendo substituída pelo uso de sondas gástricas por serem bem toleradas. Embora a nutrição enteral em crianças com câncer, segundo alguns estudos, apresente mais vantagens que a nutrição parenteral, ela ainda tem recebido pouca importância dos profissionais dessa área no Brasil.

Objective: to do a review about the enteral nutritional therapy in pediatric pacients with cancer. Methods: narrative review with systematic search in data-base PUBMED, MEDLINE, CAPES and SCIELO. Results: were used 26 scientific articles directly related about theme, 4 related references and 2 book chapters. Final considerations: for years the parenteral nutrition was the nutritional therapy principal in children cancer cases. However, this way has been replaced for tubes, to be best tolerated. Although the enteral nutrition in children with cancer, according some works, have more advantage than parenteral nutrition, it even has been less importance of the professionals this area in Brazil.